2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-164815
    S 8849-1 free base
    S 8849-1 (free base) (Tianeptine metabolite MC5) is a Tianeptine (HY-90003) metabolite that is found in plasma. The mean elimination half-lives of S 8849-1 (free base) is 7.53 h in rats. S 8849-1 (free base) is promising for research of antidepressants.
    S 8849-1 free base
  • HY-137301R
    Mycophenolic acid glucuronide (Standard)
    Mycophenolic acid glucuronide (Standard) is the analytical standard of Mycophenolic acid glucuronide. This product is intended for research and analytical applications. Mycophenolic acid glucuronide is a metabolite of the immunosuppressant mycophenolic acid (MPA). Mycophenolic acid glucuronide shows anti-tumor activity and can be used in adenocarcinoma research.
    Mycophenolic acid glucuronide (Standard)
  • HY-N7857
    19(R)-Hydroxy-prostaglandin F2α
    19(R)-Hydroxy-prostaglandin F2α (19(R)-hydroxy PGF2α) is an ω-1 hydroxylase metabolite of PGF2α found in human semen. The concentration of 19(R)-Hydroxy-PGFs compounds (F2α and F1α together) in fresh human semen is about 20 μg/mL. 19(R)-Hydroxy-prostaglandin F2α exhibits no activity at the FP receptor of the cat iris sphincter muscle at concentrations up to 1 μM.
    19(R)-Hydroxy-prostaglandin F2α
  • HY-W045132S
    N-Desbutyl bupivacaine-d6
    N-Desbutyl bupivacaine-d6 (Desbutylbupivacaine-d6) is the deuterium labeled N-Desbutyl Bupivacaine (HY-W045132). N-Desbutyl Bupivacaine (compound 100) is a metabolite of Bupivacaine (HY-B0405), an NMDA receptor inhibitor and SCN5A antagonist.
    N-Desbutyl bupivacaine-d<sub>6</sub>
  • HY-N18026
    Ginsenoside V
    Ginsenoside V is a metabolite of Ginsenoside Rb1 (HY-N0039).
    Ginsenoside V
  • HY-150162
    Thyroxine 4'-O-β-D-glucuronide
    Thyroxine 4'-O-β-D-glucuronide (T4-Glc) is a conjugate of Thyroxine (T4) and Glucuronic acid. Thyroxine 4'-O-β-D-glucuronide is a major metabolite of Thyroxine (HY-18341).
    Thyroxine 4'-O-β-D-glucuronide
  • HY-143712R
    Allolithocholic acid (Standard)
    Allolithocholic acid (Standard) is the analytical standard of Allolithocholic acid (HY-143712). This product is intended for research and analytical applications. Allolithocholic acid is an orally active metabolite of Lithocholic acid (HY-B0172). Allolithocholic acid is a dual GPBAR1 agonist (EC50 = 2.7 μM) and RORγt inverse agonist (IC50 = 3.4 μM). Allolithocholic acid modulates immune and metabolic pathways, regulates immune cell polarization, prevents M1 macrophage and Th17 CD4 cell polarization. Allolithocholic acid improves insulin sensitivity, reduces liver lipid accumulation, reverses liver immunological, inflammatory and metabolic signaling dysregulation, restores bile acid homeostasis, adipose tissue histopathology/function, and intestinal microbiota composition, modulates intestinal immunity. Allolithocholic acid can be used for the researches of cancer, inflammayion, immunology and metabolic disease.
    Allolithocholic acid (Standard)
  • HY-144141S
    Nortriptyline impurity 3-d3 hydrochloride
    Nortriptyline impurity 3-d3 (hydrochloride) is the deuterium labeled Nortriptyline impurity 3 hydrochloride.
    Nortriptyline impurity 3-d<sub>3</sub> hydrochloride
  • HY-W759719
    21-Desacetyldeflazacort-d4
    21-Desacetyldeflazacort-d4 (21-desDFZ-d4) is the deuterium labeled 21-Desacetyldeflazacort (HY-100085). 21-Desacetyldeflazacort (21-desDFZ) is the active metabolite of Deflazacort (HY-13609). Deflazacort is an anti-inflammatory and immunosuppressant. Deflazacort is an inactive pro-drug which can be rapidly converted by esterases to the active metabolite 21-desacetyldeflazacort after oral administration.
    21-Desacetyldeflazacort-d<sub>4</sub>
  • HY-N3995S
    5β-Dihydrocortisol-d6
    5β-Dihydrocortisol-d6 is the deuterium labeled 5β-Dihydrocortisol. 5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis.
    5β-Dihydrocortisol-d<sub>6</sub>
  • HY-147001
    5-O-Demethyl-28-hydroxy-Avermectin A1a
    5-O-Demethyl-28-hydroxy-Avermectin A1a is a degradation product of Avermectin B1a (HY-15308).
    5-O-Demethyl-28-hydroxy-Avermectin A1a
  • HY-143990S
    Modafinil EP impurity B-d5
    Modafinil EP impurity B-d5 is the deuterium labeled Modafinil EP impurity B.
    Modafinil EP impurity B-d<sub>5</sub>
  • HY-N0384S4
    Homovanillic acid-d3-1
    Homovanillic acid-d3-1 (Vanilacetic acid-d3-1) is deuterated labeled Homovanillic acid (HY-N0384). Homovanillic acid (Vanilacetic acid) is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.
    Homovanillic acid-d<sub>3</sub>-1
  • HY-32351S3
    Calcifediol-d9
    Calcifediol-d9 (25-hydroxy Vitamin D3-d9) is the deuterium labeled Calcifediol (HY-32351). Calcifediol (25-hydroxy Vitamin D3) is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels.
    Calcifediol-d<sub>9</sub>
  • HY-17026A
    Gemcitabine triphosphate
    Gemcitabine triphosphate (dFdCTP) is the active metabolite of Gemcitabine (HY-17026). The mechanism of Gemcitabine triphosphate cell-killing is its competition with cytidine triphosphate during DNA replication, which results in the inhibition of chain elongation. Gemcitabine triphosphate shows a Ki of 11.2 μM against DNA polymerase α and 14.4 μM against DNA polymerase ε. Gemcitabine triphosphate partially inhibits dCMP deaminase and acts as a substrate for DNA synthesis to incorporate into cellular DNA and RNA. Gemcitabine triphosphate disrupts DNA and RNA synthesis, arrests cell cycle in G0/G1 and S phases, triggers apoptosis, reduces tumor cell proliferation. Gemcitabine triphosphate can be used for the research of pancreatic cancer and non-small cell lung cancer.
    Gemcitabine triphosphate
  • HY-17530S
    Aldicarb sulfone-13C2,d3
    Aldicarb sulfone-13C2,d3 is the deuterium and 13C labeled Aldicarb sulfone (HY-17530). Aldicarb sulfone is one of the metabolites of the carbamate pesticide Aldicarb and has insecticidal activity. Aldicarb sulfone is also an inhibitor of cholinesterase.
    Aldicarb sulfone-<sup>13</sup>C<sub>2</sub>,d<sub>3</sub>
  • HY-B2150S
    4-Hydroxyantipyrine-d3
    4-Hydroxyantipyrine-d3 is the deuterium labeled 4-Hydroxyantipyrine. 4-Hydroxyantipyrine is the major metabolite of Antipyrine, can be as a biodistribution promoter. 4-Hydroxyantipyrine can increase distribution of concentration ratio of Antipyrine in the brain.
    4-Hydroxyantipyrine-d<sub>3</sub>
  • HY-121208R
    Ketanserinol (Standard)
    Cycloate (Standard) is the analytical standard of Cycloate. This product is intended for research and analytical applications. Cycloate is an active compound.
    Ketanserinol (Standard)
  • HY-Z9063
    1-epi-Regadenoson
    1-epi-Regadenoson is an αisomer impurity of Regadenoson which is a highly selective adenosine A2A receptor agonist.
    1-epi-Regadenoson
  • HY-G0008
    O-Desmethyl Mebeverine alcohol
    O-Desmethyl Mebeverine alcohol is a metabolite of Mebeverine, which is a potent α1 repector inhibitor, causing relaxation of the gastrointestinal tract.
    O-Desmethyl Mebeverine alcohol
Cat. No. Product Name / Synonyms Application Reactivity